An illustration accompanying an in-depth review article published in ACS Central Science. The article examines how tumorigenesis affects blood-brain barrier (BBB) integrity, and how nanomaterial properties affect uptake and retention in brain tissue, with the goal of creating more patient-specific, predictive treatment approaches.
This illustration demonstrates a progression of changes in the tumor microenvironment of a mouse model in the study. Shown are relative degree of BBB breakdown, large and small nanoparticle permeability across the BBB, and tumor-associated vascularization during early, middle, and late stages of tumor development.
Zachary H. Houston, PhD, et al. / The University of Queensland
© American Chemical Society