Amino Creative | Portfolio Categories Nanomedicine
Amino Creative, LLC. Specializing in conceptualization, communication, and clarity for science and medicine. Located in Boston, Massachusetts, United States
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Archive

BBB Permeability by Nanoparticles and Changes in Tumor Development

An illustration accompanying an in-depth review article published in ACS Central Science. The article examines how tumorigenesis affects blood-brain barrier (BBB) integrity, and how nanomaterial properties affect uptake and retention in brain tissue, with the goal of creating more patient-specific, predictive treatment approaches.

This illustration demonstrates a progression of changes in the tumor microenvironment of a mouse model in the study. Shown are relative degree of BBB breakdown, large and small nanoparticle permeability across the BBB, and tumor-associated vascularization during early, middle, and late stages of tumor development.

Minimum information reporting in bio-nano experimental literature

This illustration accompanies an article published in Nature Nanotechnology. It highlights the importance of  improving one of many barriers to progress in the multidisciplinary field of biological application of nanotechnology (‘bio-nano’)—that of standards of experiment reporting in scientific publication. The article proposes components in 3 main categories: material and biological characterization, and experimental protocol details.

Overcoming the Blood Brain Barrier

A series of illustration accompanying an in-depth review article published in Advanced Materials, examining the structure and functional aspects of the blood brain barrier (BBB). The article focuses on the role of nanomaterials and nanoparticles as part of evolving noninvasive therapeutic strategies designed to either bypass or cross the BBB. Many strategies of interest have the potential to exploit existing endogenous pathways—natural mechanisms of cellular transport in the central nervous system—and could be combined with novel techniques in localization and targeting.

Convergent science

This illustration accompanies an article published in the Journal of the American Chemical Society. It highlights the concept of convergent science—the intersection of [1] cumulative research (creating complex connections and clinical application by building up simple solutions), [2] identifying ideas worth pursuing (research that has greatest potential for substantial clinical benefit), [3] transparent science (open science approaches to enhance reproducibility and reliability), [4] dark data (tapping into and utilizing unreported, ‘wasted’ data), and [5] bio-nano standards (big data approaches to discovering patterns).