Amino Creative | Portfolio Categories Cells + Molecules
Amino Creative, LLC. Specializing in conceptualization, communication, and clarity for science and medicine. Located in Boston, Massachusetts, United States
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Archive

BBB Permeability by Nanoparticles and Changes in Tumor Development

An illustration accompanying an in-depth review article published in ACS Central Science. The article examines how tumorigenesis affects blood-brain barrier (BBB) integrity, and how nanomaterial properties affect uptake and retention in brain tissue, with the goal of creating more patient-specific, predictive treatment approaches.

This illustration demonstrates a progression of changes in the tumor microenvironment of a mouse model in the study. Shown are relative degree of BBB breakdown, large and small nanoparticle permeability across the BBB, and tumor-associated vascularization during early, middle, and late stages of tumor development.

Food Allergies Science Initiative

A series of illustrations created for the Food Allergies Science Initiative (FASI) at the Broad Institute, as part of their public awareness and funding campaigns.

The images provide an overview of the anatomical and cellular basis of food ‘quality control,’ involving detection by taste, smell, and specialized ‘nutrient-sensing’ and ‘toxin-sensing’ cells, joined with neural and immune pathway regulation.

Current FASI research focuses on unravelling this complex system, elucidating mechanisms of inflammatory and immune responses to particular foods, and making advances in diagnosis, prevention, and treatment.

Minimum information reporting in bio-nano experimental literature

This illustration accompanies an article published in Nature Nanotechnology. It highlights the importance of  improving one of many barriers to progress in the multidisciplinary field of biological application of nanotechnology (‘bio-nano’)—that of standards of experiment reporting in scientific publication. The article proposes components in 3 main categories: material and biological characterization, and experimental protocol details.

Overcoming the Blood Brain Barrier

A series of illustration accompanying an in-depth review article published in Advanced Materials, examining the structure and functional aspects of the blood brain barrier (BBB). The article focuses on the role of nanomaterials and nanoparticles as part of evolving noninvasive therapeutic strategies designed to either bypass or cross the BBB. Many strategies of interest have the potential to exploit existing endogenous pathways—natural mechanisms of cellular transport in the central nervous system—and could be combined with novel techniques in localization and targeting.

The Secret of Life (MIT Biology 7.012)

Several hundred illustrations for The Secret of Life, the digital textbook for MIT’s on-campus course 7.012 and online course 7.00x on Introductory Biology. The course is taught by Eric Lander, president and founding director of the Broad Institute, and professor of biology.

Redox: plant/soil biology and nutrition

Illustration series for Redox Chemicals, a bio-nutrient company that focuses on sustainable plant nutrition.

We helped to establish a brand-specific appearance to explain the basics of plant biology and soil dynamics, and to highlight key mechanistic advantages of Redox plant nutrition products and formulations that boost plant growth, quality, and yield.

Layer-by-layer assembly featured image

Technology-driven layer-by-layer assembly of nanofilms

A series of illustrations accompanying an in-depth review article published in Science, examining the interdisciplinary environment that has produced novel layer-by-layer (LBL) assembly technology. The 5 main LBL assembly approaches are discussed as it applies to producing different resulting material properties. The authors also focus on future scalability and harnessing the strengths of different types of LBL assembly for use in advancing scientific research and practical use in biomedicine, optics, membranes, among other various applications.

Bridging Bio-nano Science and Cancer Medicine (detail)

Bridging bio–nano science and cancer nanomedicine

This illustration accompanies an article published in ACS Nano. It features many issues at the interface between “bio-nano” science (research into the properties and processes of nanoscale phenomena in biological and biology-inspired structures) and cancer nanomedicine (research into the application of nanoscale materials and nanotechnology for the prevention and treatment of diseases).

The illustration serves as an overview of the key influential forces in nanomaterial engineering, current oncology research—and, to highlight ways to improve the next-generation of nanomedicines—also draws focus to existing controversies, and emerging concepts and opportunities for tumor targeting and clinical impact.